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TRAINING

All of the ESRs recruited by PET3D will be exposed to a variety of highly complementary research environments spanning different therapeutic areas: oncology, cardiovascular, neuroscience and all of the ESRs will spend at least one secondment in a different country and will have the opportunity to attend training events and consortium meetings in all of the 7 countries involved in PET3D.

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LOCAL TRAINING

Each ESR will be exposed to the following:

Cutting edge research training, technical training, generic skills training.

Cross-sectorial training – translational skills training, commercialisation.

Access to state of the art technologies in each of the beneficiary sites.

Transferrable and generic skills training – communications, presentation, writing, management, dissemination, intellectual property rights protection, dissemination and exploitation, ethical issues, entrepreneurial initiatives, CV writing and interview training available locally at each beneficiary site.

Strong collaborative bonds with each ESR, with supervisors and mentors and also with researchers in related fields, thereby laying the foundation for future continued European-wide research collaboration.

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SECONDMENTS

ESR1 - Host ABD

Secondment
AZ, May 2018, for 6 months,
For in vitro and ex-vivo profiling, and pharmacokinetic studies on 3H/14C versions of fatty acid analogues and CPT1 inhibitors.

ESR2 - Host ABD

Secondment
AMS, month 30, for 3 months,
‘for exploring full antibody or nanobody versions of the tracer.

ESR3 - Host AMS

Secondments
1. BER, month 9, for 3 months,
for design and synthesis of target compounds.

2. IMA, month 18, for 6 months,
for performing chemistry and animal studies, development of complementary skills (e.g. business, project management).

ESR4 - Host AMD

Secondments
1. ABD, month 26, for 6 months,
for evaluation of clearing agent on in vivo behaviour proteins and peptides.

2. BRU, month 33, for 2 months,
for comparing BRU’s nanobody technology products to come to best practice.

ESR5 - Host BRU

Secondments
1. ABD, month 7, for 4 months
to gain knowledge on 18F-FDR radiochemistry

2. IMA, month 24, for 6 months,
for GMP production, toxicity study, IMPD writing, training on IP.

ESR6 - Host BRU

Secondment
AZ, November 2018, for 6 months,
translational pre-clinical studies on radioisotope- and NIR-labelled nanobodies.

ESR7 - Host SAN

Secondments
1. ABD, May 2018, for 4 months,
to gain knowledge on pre-targeting strategies and related synthetic chemistry.

2. IMA, June 2019, for 4 months,
to acquire skills in image quantification and kinetic modeling.

ESR8 - Host SAN

Secondments
1. BRU, month 16, for 2 months,
to gain knowledge on nanobody technology.

2. AZ, month 28, for 6 months,
to bind an oncology compound from AstraZeneca to the NanoBite platform.

ESR9 - Host BER

Secondment
AZ, month 18, for 6 months,
for biodistribution studies through micro-dosing and drug validation studies.

ESR10 - Host BER

Secondment
IMA, month 29, for 6 months
for performing biodistribution studies and metabolite characterisation.

ESR11 - Host MUN

Secondment
IMA, month 12, for 6 months
to study therapeutic modulation of neuroinflammation via pre-clinical PET imaging.

ESR12 - Host MUN

Secondment
AZ, month 6, for 6 months
to study best modality of therapeutic intervention (e.g. anti-angiogenesis).

ESR13 - Host ABD

Secondment
AMS, month 24, for 6 months
for performing PET imaging studies on pre-targeted click tracers.

ESR14 - Host IMA

Secondments
1. BER, month 13, for 3 months
for studying a pre-targeted approach to hypoxia PET imaging.

2. MUN, month 25, for 3 months
for exploring a pre-targeted PET imaging approach to gliomas.

3. ICL, month 8 and month 20 for 2 months each
characterisation of the constructs.

ESR15 - Host AZ

Secondment
ABD, September 2018, for 6 months
to develop a [18F]-labeled tracer and perform pre-clinical studies in vivo.

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NETWORK WIDE

In addition to local training, this ETN offers cutting-edge Network-wide training opportunities, see overview in ‘Main Network Training Events & Conferences’.

Dissemination events are public conferences or symposia on:

hot scientific topics of interest to PET3D

transferrable skills/employability workshops

business-related events

These events will be of particular interest to radiopharmaceuticals/drug discovery stakeholders and students.

Schools are larger and structured training initiatives lasting from 2 days to 5 days.


Activity	Structure	Month/Duration/Location/ECTS	Main Organisers/lecturers
School in Radiopharmaceutical development	• 10 lectures of 2hr • 3 days experimental • Written exam	Month 7 / 5 days Amsterdam/ 2.5 ECTS	Prof. A.D. Windhorst (Chair and organiser), Dr D.J. Vugts, Prof G.A.M.S. van Dongen
School in Radiopharmaceuticals in Drug Discovery	• 6 lectures of 2 hr • Overview of Drug discovery & development process • Tour of site & exemplary drug discovery project	Month 13 /2 days AstraZeneca site Mölndal / 1 ECTS	Chair and Organiser: Dr. C. S. Elmore (AZ); Lecturers: Dr. J. Passchier (IMA). Lectures from Advisory Board members
School in Nanobody Theranostics	• Intensive program on molecular imaging with • 9 Lectures and • Hands-on practical training • Round table discussion	Month 25/ 4 days / Brussels/ 2 ECTS	Chair and Organiser: Prof. V. Caveliers (BRU). Lecturers: Dr. T. Lahoutte (BRU), Dr. N. Devoogdt (BRU), Dr. M. R. Zalutsky (Duke University, USA), Dr. V. Caveliers (BRU), Dr. C. Xavier (BRU), Dr. S. Hernot (BRU), Dr. S. Muyldermans (BRU).
School in Pre-clinical imaging	• In-depth training on state-of-the-art molecular imaging with • 6 plenary lectures of 2 hr and • 7 hands-on sessions on a broad spectrum of dedicated imaging technologies including μPET, μSPECT, μCT, μMRI, and optical imaging.	Month 36/ 5 days/ Muenster/ 2.5 ECTS	Chair and Organiser: Prof. A. Jacobs (MUN)

Training events are smaller, 1-day training courses/workshops, which will be open to external participants and therefore will also represent dissemination opportunities.



Activity	Structure / Content	Month/Duration/Location/ECTS	Speakers
Training Workshop in “European Regulatory Aspects in Radiopharmaceuticals”	• 6 hr training event • 4 talks • Open to public • 15 external attendees planned	Month 19 / 1 day Bergen / 0.5 ECTS	(Prof. AD Windhorst, AMS); (Dr. J. Passchier, IMA); (Dr. D. Graham, ABD). Plus invited external speaker
Training Workshop in “Integrating PET imaging in drug development: a market model for PET imaging”	• 6 hr training event • 6 talks • Open to public • 25 external attendees planned	Month 25 /1 day Brussels / 0.5 ECTS	(Prof. A. Murray, ABD); (Dr. C. Elmore, AZ) (Prof. GAMS van Dongen, AMS). Plus invited external speakers
Training Workshop in “Complementary and Transferable Skills for Scientists”	• 8 hr training event • 7 talks • Research ethics and bioethics; Scientiﬁc peer communication; Writing grant applications; Communicating science to the public and the role of media; Life after PET3D: how to make the most of your CV; IP management and its importance to researchers; Science and business: how to create a “biotech” (or other) company. • Business lunch to discuss student employability • Open to public • 20 external attendees planned	Month 31 / 1 day / San Sebastian/ 0.5 ECTS	Prof. M. Zanda (ABD, co-founder of KemoTech, www.kemotech.it) Seven external speakers will be invited, plus Advisory Board member.

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