RESEARCH WORK PACKAGES
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PET3D WORK PACKAGES OVERVIEW
Work Package 1
‘Nanoparticles and Small Molecule Tracers in Oncology PET Imaging’
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Lead Beneficiary AMS (Prof. Danielle Vugts)
ESR3 ‘Small-molecule tyrosine kinase inhibitors (TKI) PET in oncology and neurology’. Host AMS
ESR8 ’Development and evaluation of bispecific nanoparticles for T cell engagement (NanoBites): a targeted and multimodality approach to cancer therapy.’ Host SAN
ESR9 ‘Novel probes for hypoxia and NTR-reporter gene imaging.’ Host BER
Work Package 2
‘Biologicals as Tracers in Oncology PET Imaging’
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Lead Beneficiary BRU (Prof. Vicky Caveliers)
ESR4 ‘Reverse translational of Immuno-PET in oncology.’ Host AMS
ESR5 ‘Development of [18F]-FDR-nanobodies for clinical translation.’ Host BRU
ESR6 ‘Site-specific nanobody functionalization as PET imaging and therapy –theranostic tool.’ Host BRU
Work Package 3
‘Pre-targeted Labelling of Biomolecules in Oncology PET Imaging’
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Lead Beneficiary ABD (Prof. Matteo Zanda)
ESR7 ‘Synthesis and preclinical investigation of boron-enriched gold nanoparticles: a pre-targeting approach to boron neutron capture therapy.’ Host SAN
ESR13 ‘Click pre-targeted PET imaging of disease targeting antibodies.’ Host ABD
ESR14 ‘Development of pre-targeting as platform technology for biomolecule labelling’ Host IMA
Work Package 4
‘Cardiovascular PET Imaging’
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Lead Beneficiary AZ (Dr. Charles Elmore)
ESR1 ‘Fatty acid analogues and CPT1 inhibitors as PET tracers for cardiac dysfunction.’ Host ABD
ESR2 ‘Development of immuno-PET directed to thrombospondin 2 (TSP-2) for identification of hypertrophic responses of the left ventricle.’ Host ABD
ESR15 ‘Development of a radioligand and PET ligand for the MC4 receptor.’ Host AZ
Work Package 5
‘CNS PET Imaging’
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Lead Beneficiary MUN (Prof. Andreas Jacobs)
ESR10 ‘Synthesis of combined targeting molecules as 18F-tracers for PET and anticancer pro-drugs: investigation of tumor drug distribution.’ Host BER
ESR11 ‘Multi-modal and multi-tracer imaging of inflammation in stroke’ Host MUN
ESR12 ‘Multimodal two-photon microscopy and PET/MR imaging of glioma growth & angiogenesis.’ Host MUN
Work Package 6
‘Management / Dissemination’
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Lead Beneficiary ABD (Teresa Morris)
Participants: all beneficiaries.
Development of a management strategy for (1) the recruitment/secondment/training of ESRs, and (2) dissemination and sharing of knowledge facilitation between beneficiaries and external researchers/public